Search | Virtual Health Library

1.

SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion.

Leuzzi, Giuseppe; Vasciaveo, Alessandro; Taglialatela, Angelo; Chen, Xiao; Firestone, Tessa M; Hickman, Allison R; Mao, Wendy; Thakar, Tanay; Vaitsiankova, Alina; Huang, Jen-Wei; Cuella-Martin, Raquel; Hayward, Samuel B; Kesner, Jordan S; Ghasemzadeh, Ali; Nambiar, Tarun S; Ho, Patricia; Rialdi, Alexander; Hebrard, Maxime; Li, Yinglu; Gao, Jinmei; Gopinath, Saarang; Adeleke, Oluwatobi A; Venters, Bryan J; Drake, Charles G; Baer, Richard; Izar, Benjamin; Guccione, Ernesto; Keogh, Michael-Christopher; Guerois, Raphael; Sun, Lu; Lu, Chao; Califano, Andrea; Ciccia, Alberto.

Cell ; 187(4): 861-881.e32, 2024 Feb 15.

Article in English | MEDLINE | ID: mdl-38301646

2.

Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture.

Yusufova, Nevin; Kloetgen, Andreas; Teater, Matt; Osunsade, Adewola; Camarillo, Jeannie M; Chin, Christopher R; Doane, Ashley S; Venters, Bryan J; Portillo-Ledesma, Stephanie; Conway, Joseph; Phillip, Jude M; Elemento, Olivier; Scott, David W; Béguelin, Wendy; Licht, Jonathan D; Kelleher, Neil L; Staudt, Louis M; Skoultchi, Arthur I; Keogh, Michael-Christopher; Apostolou, Effie; Mason, Christopher E; Imielinski, Marcin; Schlick, Tamar; David, Yael; Tsirigos, Aristotelis; Allis, C David; Soshnev, Alexey A; Cesarman, Ethel; Melnick, Ari M.

Nature ; 589(7841): 299-305, 2021 01.

Article in English | MEDLINE | ID: mdl-33299181

3.

Examining the Roles of H3K4 Methylation States with Systematically Characterized Antibodies.

Shah, Rohan N; Grzybowski, Adrian T; Cornett, Evan M; Johnstone, Andrea L; Dickson, Bradley M; Boone, Brandon A; Cheek, Marcus A; Cowles, Martis W; Maryanski, Danielle; Meiners, Matthew J; Tiedemann, Rochelle L; Vaughan, Robert M; Arora, Neha; Sun, Zu-Wen; Rothbart, Scott B; Keogh, Michael-Christopher; Ruthenburg, Alexander J.

Mol Cell ; 72(1): 162-177.e7, 2018 10 04.

Article in English | MEDLINE | ID: mdl-30244833

4.

The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape.

Weinberg, Daniel N; Papillon-Cavanagh, Simon; Chen, Haifen; Yue, Yuan; Chen, Xiao; Rajagopalan, Kartik N; Horth, Cynthia; McGuire, John T; Xu, Xinjing; Nikbakht, Hamid; Lemiesz, Agata E; Marchione, Dylan M; Marunde, Matthew R; Meiners, Matthew J; Cheek, Marcus A; Keogh, Michael-Christopher; Bareke, Eric; Djedid, Anissa; Harutyunyan, Ashot S; Jabado, Nada; Garcia, Benjamin A; Li, Haitao; Allis, C David; Majewski, Jacek; Lu, Chao.

Nature ; 573(7773): 281-286, 2019 09.

Article in English | MEDLINE | ID: mdl-31485078

5.

Beyond the tail: the consequence of context in histone post-translational modification and chromatin research.

Weinzapfel, Ellen N; Fedder-Semmes, Karlie N; Sun, Zu-Wen; Keogh, Michael-Christopher.

Biochem J ; 481(4): 219-244, 2024 Feb 21.

Article in English | MEDLINE | ID: mdl-38353483

6.

Decoding the protein composition of whole nucleosomes with Nuc-MS.

Schachner, Luis F; Jooß, Kevin; Morgan, Marc A; Piunti, Andrea; Meiners, Matthew J; Kafader, Jared O; Lee, Alexander S; Iwanaszko, Marta; Cheek, Marcus A; Burg, Jonathan M; Howard, Sarah A; Keogh, Michael-Christopher; Shilatifard, Ali; Kelleher, Neil L.

Nat Methods ; 18(3): 303-308, 2021 03.

Article in English | MEDLINE | ID: mdl-33589837

7.

Functional organization of the S. cerevisiae phosphorylation network.

Fiedler, Dorothea; Braberg, Hannes; Mehta, Monika; Chechik, Gal; Cagney, Gerard; Mukherjee, Paromita; Silva, Andrea C; Shales, Michael; Collins, Sean R; van Wageningen, Sake; Kemmeren, Patrick; Holstege, Frank C P; Weissman, Jonathan S; Keogh, Michael-Christopher; Koller, Daphne; Shokat, Kevan M; Krogan, Nevan J.

Cell ; 136(5): 952-63, 2009 Mar 06.

Article in English | MEDLINE | ID: mdl-19269370

8.

Separation and Characterization of Endogenous Nucleosomes by Native Capillary Zone Electrophoresis-Top-Down Mass Spectrometry.

Jooß, Kevin; Schachner, Luis F; Watson, Rachel; Gillespie, Zachary B; Howard, Sarah A; Cheek, Marcus A; Meiners, Matthew J; Sobh, Amin; Licht, Jonathan D; Keogh, Michael-Christopher; Kelleher, Neil L.

Anal Chem ; 93(12): 5151-5160, 2021 03 30.

Article in English | MEDLINE | ID: mdl-33749242

9.

Dysregulation of the histone demethylase KDM6B in alcohol dependence is associated with epigenetic regulation of inflammatory signaling pathways.

Johnstone, Andrea L; Andrade, Nadja S; Barbier, Estelle; Khomtchouk, Bohdan B; Rienas, Christopher A; Lowe, Kenneth; Van Booven, Derek J; Domi, Esi; Esanov, Rustam; Vilca, Samara; Tapocik, Jenica D; Rodriguez, Keli; Maryanski, Danielle; Keogh, Michael Christopher; Meinhardt, Marcus W; Sommer, Wolfgang H; Heilig, Markus; Zeier, Zane; Wahlestedt, Claes.

Addict Biol ; 26(1): e12816, 2021 01.

Article in English | MEDLINE | ID: mdl-31373129

10.

Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan, Colm J; Roguev, Assen; Patrick, Kristin; Xu, Jiewei; Jahari, Harlizawati; Tong, Zongtian; Beltrao, Pedro; Shales, Michael; Qu, Hong; Collins, Sean R; Kliegman, Joseph I; Jiang, Lingli; Kuo, Dwight; Tosti, Elena; Kim, Hyun-Soo; Edelmann, Winfried; Keogh, Michael-Christopher; Greene, Derek; Tang, Chao; Cunningham, Pádraig; Shokat, Kevan M; Cagney, Gerard; Svensson, J Peter; Guthrie, Christine; Espenshade, Peter J; Ideker, Trey; Krogan, Nevan J.

Mol Cell ; 46(5): 691-704, 2012 Jun 08.

Article in English | MEDLINE | ID: mdl-22681890

11.

The carboxyl terminus of Rtt109 functions in chaperone control of histone acetylation.

Radovani, Ernest; Cadorin, Matthew; Shams, Tahireh; El-Rass, Suzan; Karsou, Abdel R; Kim, Hyun-Soo; Kurat, Christoph F; Keogh, Michael-Christopher; Greenblatt, Jack F; Fillingham, Jeffrey S.

Eukaryot Cell ; 12(5): 654-64, 2013 May.

Article in English | MEDLINE | ID: mdl-23457193

12.

Cancer-associated DNA Hypermethylation of Polycomb Targets Requires DNMT3A Dual Recognition of Histone H2AK119 Ubiquitination and the Nucleosome Acidic Patch.

Gretarsson, Kristjan H; Abini-Agbomson, Stephen; Gloor, Susan L; Weinberg, Daniel N; McCuiston, Jamie L; Kumary, Vishnu Udayakumar Sunitha; Hickman, Allison R; Sahu, Varun; Lee, Rachel; Xu, Xinjing; Lipieta, Natalie; Flashner, Samuel; Adeleke, Oluwatobi A; Popova, Irina K; Taylor, Hailey F; Noll, Kelsey; Windham, Carolina Lin; Maryanski, Danielle N; Venters, Bryan J; Nakagawa, Hiroshi; Keogh, Michael-Christopher; Armache, Karim-Jean; Lu, Chao.

bioRxiv ; 2024 Mar 20.

Article in English | MEDLINE | ID: mdl-38562823

13.

The replication-independent histone H3-H4 chaperones HIR, ASF1, and RTT106 co-operate to maintain promoter fidelity.

Silva, Andrea C; Xu, Xiaomeng; Kim, Hyun-Soo; Fillingham, Jeffrey; Kislinger, Thomas; Mennella, Thomas A; Keogh, Michael-Christopher.

J Biol Chem ; 287(3): 1709-18, 2012 Jan 13.

Article in English | MEDLINE | ID: mdl-22128187

14.

Ctk1 promotes dissociation of basal transcription factors from elongating RNA polymerase II.

Ahn, Seong Hoon; Keogh, Michael-Christopher; Buratowski, Stephen.

EMBO J ; 28(3): 205-12, 2009 Feb 04.

Article in English | MEDLINE | ID: mdl-19131970

15.

Multivalent binding of the tardigrade Dsup protein to chromatin promotes yeast survival and longevity upon exposure to oxidative damage.

Aguilar, Rhiannon; Khan, Laiba; Arslanovic, Nina; Birmingham, Kaylah; Kasliwal, Kritika; Posnikoff, Spike; Chakraborty, Ujani; Hickman, Allison R; Watson, Rachel; Ezell, Ryan J; Willis, Hannah E; Cowles, Martis W; Garner, Richard; Shim, Abraham; Gutierrez, Ignacio; Marunde, Matthew R; Keogh, Michael-Christopher; Tyler, Jessica K.

Res Sq ; 2023 Jul 28.

Article in English | MEDLINE | ID: mdl-37546815

16.

Structural basis of histone H2A lysine 119 deubiquitination by Polycomb Repressive Deubiquitinase BAP1/ASXL1.

Thomas, Jonathan F; Valencia-Sánchez, Marco Igor; Tamburri, Simone; Gloor, Susan L; Rustichelli, Samantha; Godínez-López, Victoria; De Ioannes, Pablo; Lee, Rachel; Abini-Agbomson, Stephen; Gretarsson, Kristjan; Burg, Jonathan M; Hickman, Allison R; Sun, Lu; Gopinath, Saarang; Taylor, Hailey; Meiners, Matthew J; Cheek, Marcus A; Rice, William; Nudler, Evgeny; Lu, Chao; Keogh, Michael-Christopher; Pasini, Diego; Armache, Karim-Jean.

bioRxiv ; 2023 Feb 23.

Article in English | MEDLINE | ID: mdl-36865140

17.

SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation.

Chen, Chun-Wei; Zhang, Linda; Dutta, Ravi; Niroula, Abhishek; Miller, Peter G; Gibson, Christopher J; Bick, Alexander G; Reyes, Jaime M; Lee, Yi-Tang; Tovy, Ayala; Gu, Tianpeng; Waldvogel, Sarah; Chen, Yi-Hung; Venters, Bryan J; Estève, Pierre-Olivier; Pradhan, Sriharsa; Keogh, Michael-Christopher; Natarajan, Pradeep; Takahashi, Koichi; Sperling, Adam S; Goodell, Margaret A.

Cell Stem Cell ; 30(11): 1503-1519.e8, 2023 11 02.

Article in English | MEDLINE | ID: mdl-37863054

18.

An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability.

Jain, Kanishk; Marunde, Matthew R; Burg, Jonathan M; Gloor, Susan L; Joseph, Faith M; Poncha, Karl F; Gillespie, Zachary B; Rodriguez, Keli L; Popova, Irina K; Hall, Nathan W; Vaidya, Anup; Howard, Sarah A; Taylor, Hailey F; Mukhsinova, Laylo; Onuoha, Ugochi C; Patteson, Emily F; Cooke, Spencer W; Taylor, Bethany C; Weinzapfel, Ellen N; Cheek, Marcus A; Meiners, Matthew J; Fox, Geoffrey C; Namitz, Kevin E W; Cowles, Martis W; Krajewski, Krzysztof; Sun, Zu-Wen; Cosgrove, Michael S; Young, Nicolas L; Keogh, Michael-Christopher; Strahl, Brian D.

Elife ; 122023 05 19.

Article in English | MEDLINE | ID: mdl-37204295

19.

Structural basis of histone H2A lysine 119 deubiquitination by Polycomb repressive deubiquitinase BAP1/ASXL1.

Thomas, Jonathan F; Valencia-Sánchez, Marco Igor; Tamburri, Simone; Gloor, Susan L; Rustichelli, Samantha; Godínez-López, Victoria; De Ioannes, Pablo; Lee, Rachel; Abini-Agbomson, Stephen; Gretarsson, Kristjan; Burg, Jonathan M; Hickman, Allison R; Sun, Lu; Gopinath, Saarang; Taylor, Hailey F; Sun, Zu-Wen; Ezell, Ryan J; Vaidya, Anup; Meiners, Matthew J; Cheek, Marcus A; Rice, William J; Svetlov, Vladimir; Nudler, Evgeny; Lu, Chao; Keogh, Michael-Christopher; Pasini, Diego; Armache, Karim-Jean.

Sci Adv ; 9(32): eadg9832, 2023 08 09.

Article in English | MEDLINE | ID: mdl-37556531

20.

A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery.

Keogh, Michael-Christopher; Kim, Jung-Ae; Downey, Michael; Fillingham, Jeffrey; Chowdhury, Dipanjan; Harrison, Jacob C; Onishi, Megumi; Datta, Nira; Galicia, Sarah; Emili, Andrew; Lieberman, Judy; Shen, Xuetong; Buratowski, Stephen; Haber, James E; Durocher, Daniel; Greenblatt, Jack F; Krogan, Nevan J.

Nature ; 439(7075): 497-501, 2006 Jan 26.

Article in English | MEDLINE | ID: mdl-16299494

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